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Search Results for " fgf 2 "

Targets Recommended: VEGFR FGFR PDGFR BTK

11

抑制剂 & 化合物

346

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T10870L	CP-547632	VEGFR; FGFR; PDGFR; BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	CP-547632是一种可口服且具有有效性、ATP 竞争性的血管内皮生长因子受体2（VEGFR-2 ）和碱性成纤维细胞生长因子（FGF）激酶F 双重抑制剂，IC50 分别为 11 nM 和 9 nM。CP-547632具有选择性，对 VEGFR2 和 bFGF 的选择性高于 EGFR，PDGFRβ 和相关的酪氨酸激酶 (TKs) 。 CP-547632具有抗肿瘤活性。
T20759	XRP44X XRP-44-X,XRP 44X,XRP-44X,XRP 44 X	Ras	GPCR/G Protein; MAPK
	XRP44X (XRP 44X) 是Ras 诱导的转录激活的抑制剂，IC50为 10 nM，通过 FGF-2 抑制 Ras-Erk-1/2 通路激活。它抑制Elk3。它还对微管有影响。
T10870	CP-547632 hydrochloride	FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	CP-547632 hydrochloride is a well-tolerated and orally-bioavailable inhibitor of the VEGFR-2 and basic FGF kinases (IC50s: 11 nM and 9 nM) with antitumor efficacy.
T36292	NSC 12
	NSC 12 is an extracellular trap for fibroblast growth factor 2 (FGF2) that binds FGF2 (Kd = 51 μM) and interferes with its interaction with FGFR1, without affecting the ability of FGF2 to bind heparin or heparin sulfate proteoglycans (HSPGs). NSC 12 also binds several other, but not all, FGF isoforms with Kd values ranging between 16 and 120 μM, preventing them from forming HSPG/FGF/FGFR ternary complexes. NSC 12 inhibits FGF-dependent angiogenesis and tumor cell proliferation in vitro and reduc...
T68935	BMS-645737
	BMS-645737 is an inhibitor of vascular endothelial growth factor (VEGF) receptor-2 and fibroblast growth factor (FGF) receptor-1. BMS-646737 has anti-angiogenic activity and was evaluated in nonclinical studies as a treatment for cancer.
T78064	Synstatin (92-119) SSTN92-119	Integrin	Cytoskeletal Signaling
	Synstatin (92-119)为一种抗肿瘤化合物，它能够抑制血管生成与癌细胞侵袭，通过下调整合素αvβ3，降低VEGF与FGF-2的活化。
T36714	Sucrose octasulfate (potassium salt)
	Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum-sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury. It can bind to exosite II of thrombin (KD = ~1.4 μM) and inhibit its catalytic activity (IC50 = 4.5 μM) and, as such, has been used as a surrogate for heparin. Furthermore, SOS has been shown to inhibit tumor growth in mouse melanoma and lung carcinoma models by pr...
T71944	FGF/PDGF/VEGF RTK Inhibitor
	FGF/PDGF/VEGF RTK Inhibitor is a potent, reversible, atp-competitive inhibitor against pdgfrβ, fgfr-1, and vegfr-2 (ic50 = 20, 90, and 240 nm, respectively) and effectively suppresses vegf-stimulated proliferation of hmvecs (ec50 = 420 nm).
T74000	CP-547632 TFA	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	CP-547632 TFA是一款口服效果显著的ATP競爭性抑制劑，针对VEGFR-2和FGF激酶具有高度选择性，IC50值分别为11 nM和9 nM。该化合物相较于EGFR和PDGFRβ，对VEGFR2和bFGF展现出更高的选择性，优于相关的酪氨酸激酶（TKs）。CP-547632 TFA还显示了显著的抗肿瘤活性。
T37598	D-Glucosamine-6-sulfate
	D-Glucosamine-6-sulfate is a naturally occurring glycosaminoglycan. It activates the glmS ribozyme from B. subtilis, a Gram-positive bacterium, when used at a concentration of 200 μM. It has been used to form polyvalent dendrimer conjugates that inhibit angiogenesis and endothelial cell proliferation induced by FGF-2 in vitro and prevent scar tissue formation in a rabbit model of glaucoma surgery.
T40546	3-Methylthienyl-carbonyl-JNJ-7706621
	3-Methylthienyl-carbonyl-JNJ-7706621 is a highly potent and selective inhibitor of cyclin-dependent kinase (CDK). It exhibits impressive IC50 values of 6.4 nM and 2 nM for CDK1/cyclin B and CDK2/cyclin A, respectively. Additionally, 3-Methylthienyl-carbonyl-JNJ-7706621 demonstrates potent inhibition against GSK-3 (IC50 = 0.041 μM) and moderate potency towards CDK4, VEGF-R2, and FGF-R2 (IC50 = 0.11 μM, 0.13 μM, and 0.22 μM, respectively). Its applications in cancer research are noteworthy.

化合物

Cat.No: T10870L

Target: VEGFR, FGFR, PDGFR, BTK

Cat.No: T20759

Synonym: XRP-44-X,XRP 44X,XRP-44X,XRP 44 X

Target: Ras

CP-547632 hydrochloride

Cat.No: T10870

Target: FGFR

Cat.No: T36292

Cat.No: T68935

Synstatin (92-119)

Cat.No: T78064

Synonym: SSTN92-119

Target: Integrin

Sucrose octasulfate (potassium salt)

Cat.No: T36714

FGF/PDGF/VEGF RTK Inhibitor

Cat.No: T71944

Cat.No: T74000

Target: VEGFR

D-Glucosamine-6-sulfate

Cat.No: T37598

3-Methylthienyl-carbonyl-JNJ-7706621

Cat.No: T40546

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00749	FGF-2 Protein, Human, Recombinant fibroblast growth factor 2 (basic),FGF-	Human	E. coli
	FGF-2 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 16.5 kDa and the accession number is P09038-4.
TMPY-00210	FGF-2 Protein, Mouse, Recombinant (His) Fgfb,bFGF,Fgf-2,fibrobla...	Mouse	E. coli
	FGF-2 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 18.5 kDa and the accession number is P15655.
TMPJ-00842	FGF-2 Protein, Rat, Recombinant bFGF,Heparin-Binding Growth Factor 2,F...	Rat	E. coli
	FGF-basic is a members of the Fibroblast Growth Factors (FGFs) family. The family constitutes a large family of proteins involved in many aspects of development including cell proliferation, growth, and differentiation. They act on several cell types to regulate diverse physiologic functions including angiogenesis, cell growth, pattern formation, embryonic development, metabolic regulation, cell migration, neurotrophic effects, and tissue repair. FGF-basic is a non-glycosylated heparin binding g...
TMPJ-00037	FGF-2 Protein, Mouse, Recombinant Fibroblast Growth Factor 2,bFGF,HBGF-2...	Mouse	E. coli
	FGF basic is one of 22 mitogenic proteins of the FGF family, which show 35-60% amino acid conservation. Unlike other FGFs, FGF acidic and basic lack signal peptides and are secreted by an alternate pathway. The 17 kDa mouse sequence has 98% aa identity with rat, and 95% identity with human, bovine, and sheep FGF basic. Binding of FGF to heparin or cell surface HSPG is necessary for binding, dimerization and activation of tyrosine kinase FGF receptors. FGF basic binds other proteins, polysacchari...
TMPJ-00039	FGF-2 Protein, Human, Recombinant (K128N) FGF2,bFGF,FGFB,Heparin-b...	Human	E. coli
	Fibroblast growth factors (FGF) are a family of heparin-binding secreted proteins that stimulate cell proliferation and differentiation in a wide variety of tissues. FGFs play important roles in diverse biological functions both in vivo and in vitro, including mitogenesis, cellular migration, differentiation, angiogenesis, and wound healing. Human embryonic stem cell (hESC) cultures require FGF basic (also known as FGF-2 or bFGF) in cell culture media to remain in an undifferentiated and pluripo...
TMPJ-00040	FGF-2 Protein, Human,Recombinant (Q65I, C96S, N111G) FGF-2,Fibroblast growth factor 2,...	Human	E. coli
	Fibroblast growth factors (FGF) are a family of heparin-binding secreted proteins that stimulate cell proliferation and differentiation in a wide variety of tissues. FGFs play important roles in diverse biological functions both in vivo and in vitro, including mitogenesis, cellular migration, differentiation, angiogenesis, and wound healing. Human embryonic stem cell (hESC) cultures require FGF basic (also known as FGF-2 or bFGF) in cell culture media to remain in an undifferentiated and pluripo...
TMPK-00096	FGF-10 Protein (Primary Amine Labeling), Human, Recombinant, Biotinylated FGF-10,KGF2	Human	E. coli
	Fibroblast growth factor 10 (FGF10) regulates multiple stages of structural lung morphogenesis, cellular differentiation, and the response to injury. As a driver of lung airway branching morphogenesis, FGF10 signaling defects during development lead to neonatal lung disease. Lung diseases impact patients across the lifespan, from infants in the first minutes of life through the aged population. Congenital abnormalities of lung structure can cause lung disease at birth or make adults more suscept...
TMPY-03261	CNPY2 Protein, Human, Recombinant (His) canopy FGF signaling regulator 2,HP10390,Z...	Human	HEK293
	CNPY2 is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain. CNPY2 enhances migration of C6 glioma cells through phosphorylation of the myosin regulatory light chain. It is expressed in different tissues, including brain. Overexpression of CNPY2 enhanced the motility of glioma cells measured in matrigel invasion chambers and using a scratch assay. Downregulation of CNPY2 by RNA interference significantly decreased glioma cell migration and...
TMPJ-00388	FGFR2IIIc Protein, Human, Recombinant (hFc) FGFR2,FGFR2 beta,FGF...	Human	Human Cells
	FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. A frequent splici...
TMPJ-00389	FGFR2 alpha (IIIc) Protein, Human, Recombinant (hFc) FGFR2,FGFR2IIIc,FGF<...	Human	Human Cells
	FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. A frequent splici...
TMPK-01322	FGFR4 Protein, Rhesus macaque, Recombinant (His) TKF,JTK2,FGF R4,CD334,FGFR-4,...	Rhesus macaque	HEK293
	Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase.Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1...
TMPH-00368	FGF-2 Protein, Chicken, Recombinant (His)	Chicken	Yeast
	Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis.
TMPK-00390	FGFR3 alpha (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated FGFR3,JTK4,ACH,FGF R3,FGFR2	Human	HEK293
	Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell p...
TMPK-00378	FGFR4 beta Protein, Human, Recombinant (His & Avi) JTK2,CD334,FGFR4 β,FGF R4,TKF,	Human	HEK293
	Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase.Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1...
TMPK-00381	FGFR4 Protein, Human, Recombinant (His & Avi), Biotinylated CD334,FGFR-4,FGFR4,FGF R4,TKF,JTK...	Human	HEK293
	Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase.Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1...
TMPK-00379	FGFR4 Protein, Human, Recombinant (His & Avi) CD334,FGFR4,TKF,FGF R4,FGFR-4,MGC...	Human	HEK293
	Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase.Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1...
TMPK-00380	FGFR4 beta Protein, Human, Recombinant (His & Avi), Biotinylated FGFR4,TKF,FGFR4 β,FGF R4,FGF<...	Human	HEK293
	Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase.Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1...
TMPJ-00390	FGFR2IIIb Protein, Human, Recombinant (hFc) FGFR2,FGFR2 beta,FGF...	Human	Human Cells
	FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. A frequent splici...
TMPJ-00391	FGFR2IIIb Protein, Human, Recombinant (aa 22-378, hFc) FGF R2b,KGFR,BFR-1,FGFR2...	Human	Human Cells
	FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. A frequent splici...
TMPK-00387	FGFR3 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated HSFGFR3EX,FGF R3,EC 2.7.10,CD333,...	Human	HEK293
	Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell p...
TMPK-00388	FGFR3 alpha (IIIb) Protein, Human, Recombinant (His & Avi) HSFGFR3EX,FGF R3,ACH,CD333,FGFR	Human	HEK293
	Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell p...
TMPK-00389	FGFR3 beta (IIIb) Protein, Human, Recombinant (His & Avi) FGFR3,FGFR3 β (IIIb),CD333,FGF R3...	Human	HEK293
	Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell p...
TMPK-00385	FGFR3 beta (IIIc) Protein, Human, Recombinant (His & Avi) FGFR3,EC 2.7.10,FGFR3 β (IIIc),CD...	Human	HEK293
	Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell p...
TMPK-00386	FGFR3 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated ACH,CD333,EC 2.7.10,FGFR3 α (IIIc),FGF...	Human	HEK293
	Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell p...
TMPH-00369	FGF-2 Protein, Chicken, Recombinant (His & Myc)	Chicken	E. coli
	Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis.
TMPK-00391	FGFR3 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated HSFGFR3EX,FGFR3,FGF R3,ACH,CD333,...	Human	HEK293
	Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell p...
TMPK-00384	FGFR3 alpha (IIIc) Protein, Human, Recombinant (His & Avi) CD333,EC 2.7.10,JTK4,FGFR3 α (IIIc),FG...	Human	HEK293
	Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell p...
TMPK-00686	FGFR3 alpha (IIIb) Protein, Mouse, Recombinant (His) CEK,CD333,HSFGFR3EX,FGFR3,FGF R3,...	Mouse	HEK293
	Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell p...
TMPY-02907	FGF-19 Protein, Human, Recombinant fibroblast growth factor 19,FGF19	Human	E. coli
	FGF19, also known as FGF-19, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF19 interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL, KLB and heparan sulfate glycosaminoglyca...
TMPY-05004	FGF-4 Protein, Human, Recombinant HST-1,KFGF,fibroblast growth factor 4,HSTF1,K-F...	Human	E. coli
	FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specification of both blood and skeletal muscle lineages. Fibroblast growth factor 4 (FGF4) signaling induces differentiation from embryonic stem cells (ESCs) via the phosphorylation of downstream molecules such as mitogen-activated protein kinase/extracellular signal-related kinase (MEK) a...
TMPY-00403	FGF-7/KGF Protein, Human, Recombinant (His) fibroblast growth factor 7,KGF,成纤维细胞生长因子,HBGF-7	Human	E. coli
	Fibroblast growth factor 7 (FGF7) is a member of the fibroblast growth factor (FGF) family of proteins. FGF7 plays an important role in regulating the proliferation, migration, and differentiation of cells. FGF7 is of stromal origin and produces a paracrine effect on epithelial cells. FGF7 is a mesenchyme-specific heparin-binding growth factor that binds FGF receptor 2 (FGFR2) to regulate numerous cellular and physiological processes. FGF7/FGFR2 promotes invasion and migration in human gastric c...
TMPY-01011	FGFR1 Protein, Human, Recombinant (His) KAL2,FLT2,FGFBR,HRTFDS,OGD,FLG,HB...	Human	HEK293
	FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind heparan sulfate glyc...
TMPY-06036	FGFR1 Protein, Human, Recombinant (alpha (IIIb), His) FGFR-1,FLG,CD331,HH2,FLT2,KAL...	Human	HEK293
	FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind heparan sulfate glyc...
TMPY-06034	FGFR1 Protein, Human, Recombinant (beta (IIIb), His) FLG,CD331,N-SAM,HBGFR,HRTFDS,BFGFR,OGD,KAL2	Human	HEK293
	FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind heparan sulfate glyc...
TMPK-00847	FGFR2 beta (IIIb) Protein, Mouse, Recombinant (His) FGFR2 β (IIIb),KGFR,BEK,CD332,K-s...	Mouse	HEK293
	Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. Multiple forms of FGF R1 - 3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGF R1 and 2 results in receptors...
TMPK-00397	FGFR2 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated K-sam,CD332,KGFR,Keratinocyte growth factor recepto...	Human	HEK293
	Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. Multiple forms of FGF R1 - 3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGF R1 and 2 results in receptors...
TMPK-00475	FGFR2 beta (IIIb) Protein, Cynomolgus, Recombinant (His) K-sam,KSAM,KGFR,CD332,Keratinocyte growth factor re...	Cynomolgus	HEK293
	Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. Multiple forms of FGF R1 - 3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGF R1 and 2 results in receptors...
TMPK-00396	FGFR2 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated BFR-1,FGF R2a,TK25,TK14,BEK,BBDS,...	Human	HEK293
	Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. Multiple forms of FGF R1 - 3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGF R1 and 2 results in receptors...
TMPK-00400	FGFR2 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated Fibroblast growth factor receptor 2,KGFR,FGF	Human	HEK293
	Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. Multiple forms of FGF R1 - 3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGF R1 and 2 results in receptors...
TMPK-00399	FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi), Biotinylated Keratinocyte growth factor receptor,K-sam,BEK,FGFR<...	Human	HEK293
	Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. Multiple forms of FGF R1 - 3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGF R1 and 2 results in receptors...
TMPY-02838	FGFBP3 Protein, Human, Recombinant (His) C10orf13,FGF-BP3,fibroblast growth factor binding p...	Human	Baculovirus-Insect Cells
	FGFBP3 is a member of the fibroblast growth factor-binding protein family. Members of this family binds and activates FGF-1 and FGF-2, thereby contributing to tumor angiogenesis. Fibroblast growth factors (FGFs) are important regulators of cell migration, proliferation and differentiation, e.g., during embryogenesis and wound healing, and under several pathological conditions including tumor growth and tumor angiogenesis. Expression of FGF-BP increases after injury to murine and human skin, in p...
TMPH-02135	SPRED1 Protein, Human, Recombinant (His & Myc & SUMO)	Human	E. coli
	Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow. Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2. Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin. Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells.
TMPK-00398	FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi) Fibroblast growth factor receptor 2,CD332,...	Human	HEK293
	Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. Multiple forms of FGF R1 - 3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGF R1 and 2 results in receptors...
TMPY-03578	FLRT2 Protein, Mouse, Recombinant (His) FLRT2,fibronectin leucine rich transmembrane protei...	Mouse	HEK293
	Fibronectin Leucine-Rich Transmembrane (FLRT) proteins are glycosylated membrane proteins expressed at the cell surface which localise in a homophilic manner to cell-cell contacts expressing the focal adhesion marker vinculin. FLRT1, FLRT2, and FLRT3, the three genes encode putative type I transmembrane proteins, each containing 10 leucine-rich repeats (LRR), a type III fibronectin (FN) domain, followed by the transmembrane region, and a short cytoplasmic tail. FLRT family members may function i...
TMPY-04025	CEP57 Protein, Human, Recombinant (GST) MVA2,PIG8,TSP57,centrosomal protein 57kDa	Human	E. coli
	CEP57 is a centrosomal protein and is involved in nucleating and stabilizing microtubules. CEP57 was initially identified as a regulator of centriole overduplication in an RNA interference screen. There is a link between altered microenvironmental signaling cues such as FGF-2 overexpression and mitotic instability and provide a rationale for the therapeutic targeting of the FGF-2/FGFR1/CEP57 axis in prostate cancer. CEP57 is involved in intracellular transport processes, and its overexpression c...
TMPY-02048	FLRT2 Protein, Human, Recombinant (His) UNQ232/PRO265,fibronectin leucine...	Human	HEK293
	Fibronectin Leucine-Rich Transmembrane (FLRT) proteins are glycosylated membrane proteins expressed at the cell surface which localise in a homophilic manner to cell-cell contacts expressing the focal adhesion marker vinculin. FLRT1, FLRT2, and FLRT3, the three genes encode putative type I transmembrane proteins, each containing 10 leucine-rich repeats (LRR), a type III fibronectin (FN) domain, followed by the transmembrane region, and a short cytoplasmic tail. FLRT family members may function i...
TMPY-04206	FGF-7/KGF Protein, Mouse, Recombinant (His) Kgf,fibroblast growth factor 7,成纤维细胞生长因子	Mouse	E. coli
	Fibroblast growth factor 7 (FGF7) is a member of the fibroblast growth factor (FGF) family of proteins. FGF7 plays an important role in regulating the proliferation, migration, and differentiation of cells. FGF7 is of stromal origin and produces a paracrine effect on epithelial cells. FGF7 is a mesenchyme-specific heparin-binding growth factor that binds FGF receptor 2 (FGFR2) to regulate numerous cellular and physiological processes. FGF7/FGFR2 promotes invasion and migration in human gastric c...
TMPY-02032	FLRT1 Protein, Human, Recombinant (His) SPG68,fibronectin leucine rich transmembrane protein 1	Human	HEK293
	The three fibronectin leucine-rich repeat transmembrane (FLRT) proteins contain 10 leucine-rich repeats (LRR), a type III fibronectin (FN) domain, followed by the transmembrane region, and a short cytoplasmic tail. FLRT1 is expressed in kidney and brain, which is a target for tyrosine phosphorylation mediated by FGFR1 and implicates a non-receptor Src family kinase (SFK). All FLRTs can interact with FGFR1 and FLRTs can be induced by the activation of FGF signalling by FGF-2. The phosphorylation ...
TMPJ-00715	FGF-19 Protein, Human, Recombinant (His) FGF-19,Fibroblast growth factor 19,FGF19	Human	E. coli
	Fibroblast growth factor 19 (FGF19) is a secreted protein which belongs to the FGFs family. FGF19 is expressed in fetal brain, cartilage, retina, and adult gall bladder. FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF receptors (FGFRs): FGFR-1, -2, -3, and -4, all with intrinsic tyrosine kinase activity. FGFRs can be important for regulation of glucose and lipid homeostasis. FGF19 has important roles as a hormone produced in the ileum in response to bile ...
TMPY-03230	ESM1 Protein, Mouse, Recombinant (His) 0610042H23Rik,ESM-1,endothelial cell-speci...	Mouse	Baculovirus-Insect Cells
	ESM1 is a secreted protein which is produced by adipocytes. It has been noticed that ESM1 may play some role in obesity-associated vascular disease since circulating ESM-1 levels are reduced in the overweight and obese. ESM1 is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of ESM1 gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. Recently, ESM1 has been described as a specific biomarker...
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重组蛋白

FGF-2 Protein, Human, Recombinant

Cat.No: TMPY-00749

Species: Human

Expression System: E. coli

FGF-2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00210

Species: Mouse

Expression System: E. coli

FGF-2 Protein, Rat, Recombinant

Cat.No: TMPJ-00842

Species: Rat

Expression System: E. coli

FGF-2 Protein, Mouse, Recombinant

Cat.No: TMPJ-00037

Species: Mouse

Expression System: E. coli

FGF-2 Protein, Human, Recombinant (K128N)

Cat.No: TMPJ-00039

Species: Human

Expression System: E. coli

FGF-2 Protein, Human,Recombinant (Q65I, C96S, N111G)

Cat.No: TMPJ-00040

Species: Human

Expression System: E. coli

FGF-10 Protein (Primary Amine Labeling), Human, Recombinant, Biotinylated

Cat.No: TMPK-00096

Species: Human

Expression System: E. coli

CNPY2 Protein, Human, Recombinant (His)

Cat.No: TMPY-03261

Species: Human

Expression System: HEK293

FGFR2IIIc Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00388

Species: Human

Expression System: Human Cells

FGFR2 alpha (IIIc) Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00389

Species: Human

Expression System: Human Cells

FGFR4 Protein, Rhesus macaque, Recombinant (His)

Cat.No: TMPK-01322

Species: Rhesus macaque

Expression System: HEK293

FGF-2 Protein, Chicken, Recombinant (His)

Cat.No: TMPH-00368

Species: Chicken

Expression System: Yeast

FGFR3 alpha (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00390

Species: Human

Expression System: HEK293

FGFR4 beta Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00378

Species: Human

Expression System: HEK293

FGFR4 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00381

Species: Human

Expression System: HEK293

FGFR4 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00379

Species: Human

Expression System: HEK293

FGFR4 beta Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00380

Species: Human

Expression System: HEK293

FGFR2IIIb Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00390

Species: Human

Expression System: Human Cells

FGFR2IIIb Protein, Human, Recombinant (aa 22-378, hFc)

Cat.No: TMPJ-00391

Species: Human

Expression System: Human Cells

FGFR3 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00387

Species: Human

Expression System: HEK293

FGFR3 alpha (IIIb) Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00388

Species: Human

Expression System: HEK293

FGFR3 beta (IIIb) Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00389

Species: Human

Expression System: HEK293

FGFR3 beta (IIIc) Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00385

Species: Human

Expression System: HEK293

FGFR3 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00386

Species: Human

Expression System: HEK293

FGF-2 Protein, Chicken, Recombinant (His & Myc)

Cat.No: TMPH-00369

Species: Chicken

Expression System: E. coli

FGFR3 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00391

Species: Human

Expression System: HEK293

FGFR3 alpha (IIIc) Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00384

Species: Human

Expression System: HEK293

FGFR3 alpha (IIIb) Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00686

Species: Mouse

Expression System: HEK293

FGF-19 Protein, Human, Recombinant

Cat.No: TMPY-02907

Species: Human

Expression System: E. coli

FGF-4 Protein, Human, Recombinant

Cat.No: TMPY-05004

Species: Human

Expression System: E. coli

FGF-7/KGF Protein, Human, Recombinant (His)

Cat.No: TMPY-00403

Species: Human

Expression System: E. coli

FGFR1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01011

Species: Human

Expression System: HEK293

FGFR1 Protein, Human, Recombinant (alpha (IIIb), His)

Cat.No: TMPY-06036

Species: Human

Expression System: HEK293

FGFR1 Protein, Human, Recombinant (beta (IIIb), His)

Cat.No: TMPY-06034

Species: Human

Expression System: HEK293

FGFR2 beta (IIIb) Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00847

Species: Mouse

Expression System: HEK293

FGFR2 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00397

Species: Human

Expression System: HEK293

FGFR2 beta (IIIb) Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00475

Species: Cynomolgus

Expression System: HEK293

FGFR2 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00396

Species: Human

Expression System: HEK293

FGFR2 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00400

Species: Human

Expression System: HEK293

FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi), Biotinylated

Cat.No: TMPK-00399

Species: Human

Expression System: HEK293

FGFBP3 Protein, Human, Recombinant (His)

Cat.No: TMPY-02838

Species: Human

Expression System: Baculovirus-Insect Cells

SPRED1 Protein, Human, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-02135

Species: Human

Expression System: E. coli

FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi)

Cat.No: TMPK-00398

Species: Human

Expression System: HEK293

FLRT2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03578

Species: Mouse

Expression System: HEK293

CEP57 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04025

Species: Human

Expression System: E. coli

FLRT2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02048

Species: Human

Expression System: HEK293

FGF-7/KGF Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04206

Species: Mouse

Expression System: E. coli

FLRT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02032

Species: Human

Expression System: HEK293

FGF-19 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00715

Species: Human

Expression System: E. coli

ESM1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03230

Species: Mouse

Expression System: Baculovirus-Insect Cells

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